Which medication is associated with iris darkening as per the cautions?

Which medication is associated with iris darkening as per the cautions?

• A. Dorzolamide
• B. Timolol
• C. Latanoprost
• D. Neomycin

Answer: (A)

Iris darkening happens with certain glaucoma medicines called prostaglandin analogs. These drugs can stimulate melanocytes in the iris, increasing melanin content in the iris stroma. The color change develops slowly over months and is usually permanent or only slowly reversible, and it’s more noticeable in people with lighter-colored irises. Other common glaucoma meds, such as dorzolamide (a carbonic anhydrase inhibitor), timolol (a beta-blocker), or neomycin, don’t carry this pigmentation caution. So the medication most associated with iris darkening is a prostaglandin analog like latanoprost.

Iris darkening happens with certain glaucoma medicines called prostaglandin analogs. These drugs can stimulate melanocytes in the iris, increasing melanin content in the iris stroma. The color change develops slowly over months and is usually permanent or only slowly reversible, and it’s more noticeable in people with lighter-colored irises. Other common glaucoma meds, such as dorzolamide (a carbonic anhydrase inhibitor), timolol (a beta-blocker), or neomycin, don’t carry this pigmentation caution. So the medication most associated with iris darkening is a prostaglandin analog like latanoprost.